General Information of This Linker
Linker ID
LIN0FOOUN
Name
JP7615189B2+ADC37+Linker
Linker Type
Cathepsin-cleavable linker
Antibody-Linker Relation
Cleavable
Structure
Formula
C128H189N15O66
Isosmiles
CC(N[C@@H]([C@]1([H])[C@H](O)[C@H](O)CO)[C@@H](O)C[C@@](OC[C@@H]2[C@H](O)[C@H](O)[C@@H](O)C(O[C@H]([C@H]3CO)[C@H](O)[C@@H](NC(C)=O)[C@@H](O3)O[C@H](C(O[C@@H]4C(O)=C(O[C@H]5[C@H](O)[C@@H](NC(C)=O)[C@H](O[C@H]6C(O)C(NC(C)=O)=CO[C@@H]6CO[C@H](O7)[C@@H](O)[C@H](O)[C@H](O)[C@@H]7C)O[C@@H]5CO)O[C@H](CO[C@@H](O8)[C@@H](OC(O9)[C@H](NC(C)=O)[C@@H](O)[C@H](O[C@H]%10[C@H](O)[C@@H](O)[C@@H](O)[C@H](O%10)CO)[C@H]9CO)[C@@H](O)[C@H](O)[C@H]8CO)[C@H]4O)O%11)[C@@H](O)[C@H](O)[C@H]%11CO)O2)(O1)C(NCCOCCOCCOCCN(N=N%12)C(C%13=C(CN%14C(CCC(NCC(NCC(NC%15(CCC%15)C(N[C@@H]([C@@H](C)CC)C(NC(C=C%16)=CC=C%16CO)=O)=O)=O)=O)=O)=O)C=CC=C%13)=C%12C%17=C%14C=CC=C%17)=O)=O
InChI
InChI=1S/C128H189N15O66/c1-9-51(2)80(115(183)137-60-21-19-58(39-144)20-22-60)138-125(184)127(25-14-26-127)139-78(161)37-131-77(160)36-130-76(159)23-24-79(162)142-38-59-15-10-11-16-61(59)86-81(62-17-12-13-18-64(62)142)140-141-143(86)28-30-187-32-34-188-33-31-186-29-27-129-126(185)128(35-65(157)82(133-54(5)153)111(209-128)89(165)66(158)40-145)192-50-74-93(169)100(176)105(181)121(201-74)204-108-71(45-150)199-118(85(97(108)173)136-57(8)156)208-114-102(178)92(168)69(43-148)196-124(114)206-112-94(170)73(48-191-123-113(101(177)91(167)68(42-147)195-123)207-117-84(135-56(7)155)96(172)107(70(44-149)198-117)203-120-104(180)99(175)90(166)67(41-146)194-120)200-122(106(112)182)205-109-72(46-151)197-116(83(95(109)171)134-55(6)154)202-110-75(189-47-63(88(110)164)132-53(4)152)49-190-119-103(179)98(174)87(163)52(3)193-119/h10-13,15-22,47,51-52,65-75,80,82-85,87-105,107-114,116-121,123-124,144-151,157-158,163-182H,9,14,23-46,48-50H2,1-8H3,(H,129,185)(H,130,159)(H,131,160)(H,132,152)(H,133,153)(H,134,154)(H,135,155)(H,136,156)(H,137,183)(H,138,184)(H,139,161)/t51-,52-,65-,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,80-,82+,83+,84+,85+,87+,88?,89+,90-,91+,92+,93-,94+,95+,96+,97+,98+,99-,100-,101-,102-,103-,104+,105+,107+,108+,109+,110+,111+,112-,113-,114-,116-,117?,118-,119+,120-,121?,123-,124?,128+/m0/s1
InChIKey
NFZDUZBFPUYVDA-NBQPXUCOSA-N
Pharmaceutical Properties
Molecule Weight
2993.959
Polar area
1199.54
Complexity
.
xlogp Value
-19.5654
Heavy Count
209
Rot Bonds
65
Hbond acc
69
Hbond Donor
41
Each Antibody-drug Conjugate Related to This Linker