Linker Information
General Information of This Linker
| Linker ID |
LIN0FKHKP
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN113874046B-ADC-1-LINKER
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C46H69N9O14
|
|||||
| Isosmiles |
CC([C@H](NC(CCOCCOCCNC1CCN(CC1)C(CCN2C3=C(C=C2CN(NC)C)C=CC=N3)=O)=O)C(N[C@@H](C)C(NC4=C(OC(O5)[C@H](O)[C@@H](O)[C@H](O)[C@H]5C(O)=O)C=C(CO)C=C4)=O)=O)C
|
|||||
| InChI |
InChI=1S/C46H69N9O14/c1-27(2)37(44(63)50-28(3)43(62)51-33-9-8-29(26-56)23-34(33)68-46-40(61)38(59)39(60)41(69-46)45(64)65)52-35(57)13-19-66-21-22-67-20-15-48-31-10-16-54(17-11-31)36(58)12-18-55-32(25-53(5)47-4)24-30-7-6-14-49-42(30)55/h6-9,14,23-24,27-28,31,37-41,46-48,56,59-61H,10-13,15-22,25-26H2,1-5H3,(H,50,63)(H,51,62)(H,52,57)(H,64,65)/t28-,37-,38-,39-,40+,41-,46?/m0/s1
|
|||||
| InChIKey |
NPHRDERJDABLET-MFUMHZOOSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
972.107
|
Polar area
|
307.87
|
||
|
Complexity
|
2084.011945
|
xlogp Value
|
-0.956
|
|||
|
Heavy Count
|
69
|
Rot Bonds
|
26
|
|||
|
Hbond acc
|
18
|
Hbond Donor
|
10
|
|||
Each Antibody-drug Conjugate Related to This Linker