Linker Information
General Information of This Linker
| Linker ID |
LIN0FGARK
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|---|---|---|---|---|---|---|
| Linker Name |
CN110997010A ADC-5 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C56H76N10O19S3
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| Isosmiles |
C[C@H](NC([C@@H](NC(CSCCC(N1CN(C(C=C)=O)CN(C(C=C)=O)C1)=O)=O)C(C)C)=O)C(NC2=CC=C(COC(NC(CSC(CC3=O)C(N3CCCCCC(O)=O)=O)C(NC(C(O)=O)CSC(C4=O)CC(N4CCCCCC(O)=O)=O)=O)=O)C=C2)=O
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| InChI |
InChI=1S/C56H76N10O19S3/c1-6-42(68)62-30-63(43(69)7-2)32-64(31-62)44(70)20-23-86-29-41(67)61-49(33(3)4)52(79)57-34(5)50(77)58-36-18-16-35(17-19-36)26-85-56(84)60-37(27-87-39-24-45(71)65(53(39)80)21-12-8-10-14-47(73)74)51(78)59-38(55(82)83)28-88-40-25-46(72)66(54(40)81)22-13-9-11-15-48(75)76/h6-7,16-19,33-34,37-40,49H,1-2,8-15,20-32H2,3-5H3,(H,57,79)(H,58,77)(H,59,78)(H,60,84)(H,61,67)(H,73,74)(H,75,76)(H,82,83)/t34-,37?,38?,39?,40?,49-/m0/s1
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| InChIKey |
HEXAOKRADCKVET-GOOZWCIWSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1289.476
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Polar area
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402.32
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Complexity
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2636.818233
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xlogp Value
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1.3134
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Heavy Count
|
88
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Rot Bonds
|
37
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Hbond acc
|
19
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker