Linker Information
General Information of This Linker
| Linker ID |
LIN0FFWWI
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| Linker Name |
Linker of ADC2-43
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C50H78N12O17
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(OC[C@H]1[C@@]2([H])CCC(N=NN3)=C3CC[C@]21[H])=O)=O)CCC(NC4[C@H](O)[C@H](O)[C@@H](C(N)=O)O4)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC5=CC=C(CO)C=C5)=O)=O)C
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| InChI |
InChI=1S/C50H78N12O17/c1-28(2)40(47(71)57-36(4-3-16-53-49(52)72)45(69)55-30-7-5-29(26-63)6-8-30)59-46(70)37(13-14-38(64)58-48-42(67)41(66)43(79-48)44(51)68)56-39(65)15-18-74-20-22-76-24-25-77-23-21-75-19-17-54-50(73)78-27-33-31-9-11-34-35(61-62-60-34)12-10-32(31)33/h5-8,28,31-33,36-37,40-43,48,63,66-67H,3-4,9-27H2,1-2H3,(H2,51,68)(H,54,73)(H,55,69)(H,56,65)(H,57,71)(H,58,64)(H,59,70)(H3,52,53,72)(H,60,61,62)/t31-,32+,33-,36-,37-,40-,41-,42+,43-,48?/m0/s1
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| InChIKey |
FCIRVZWHUNIHJS-UJLSQRHCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1119.241
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Polar area
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430.45
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Complexity
|
2160.975448
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xlogp Value
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-2.7533
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Heavy Count
|
79
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Rot Bonds
|
35
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Hbond acc
|
19
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker