Linker Information
General Information of This Linker
| Linker ID |
LIN0EUGTC
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| Linker Name |
Mal-Ile-Val
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C20H33N5O5
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| Isosmiles |
CCC(C)C(NC(=O)C(N)C(C)C)C(=O)NCCNC(=O)CCN1C(=O)C=CC1=O
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| InChI |
InChI=1S/C20H33N5O5/c1-5-13(4)18(24-19(29)17(21)12(2)3)20(30)23-10-9-22-14(26)8-11-25-15(27)6-7-16(25)28/h6-7,12-13,17-18H,5,8-11,21H2,1-4H3,(H,22,26)(H,23,30)(H,24,29)
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| InChIKey |
ONGKJQVWBCDRPZ-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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423.514
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Polar area
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150.7
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Complexity
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30
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xlogp Value
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-0.9519
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Heavy Count
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30
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Rot Bonds
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12
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Hbond acc
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6
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
1F6-Ile-Val-AF [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
3.00 ng/mL
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Positive CD70 expression (CD70+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Renal cell carcinoma | 786-O cells | CVCL_1051 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
3.00 ng/mL
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Positive CD70 expression (CD70+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Hodgkin lymphoma | L-428 cells | CVCL_1361 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
4.00 ng/mL
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Positive CD70 expression (CD70+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Clear cell renal cell carcinoma | Caki-1 cells | CVCL_0234 | ||
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