Linker Information
General Information of This Linker
| Linker ID |
LIN0ETHBR
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|---|---|---|---|---|---|---|
| Linker Name |
Mc-EVC-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C33H47N7O10
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| Isosmiles |
CC(C)C(NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CCC(O)=O)=O)C(N[C@H](C(NC2=CC=C(CO)C=C2)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C33H47N7O10/c1-20(2)29(32(49)38-23(7-6-17-35-33(34)50)30(47)36-22-11-9-21(19-41)10-12-22)39-31(48)24(13-16-28(45)46)37-25(42)8-4-3-5-18-40-26(43)14-15-27(40)44/h9-12,14-15,20,23-24,29,41H,3-8,13,16-19H2,1-2H3,(H,36,47)(H,37,42)(H,38,49)(H,39,48)(H,45,46)(H3,34,35,50)/t23-,24-,29?/m0/s1
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| InChIKey |
ZHXKYSJOEUDUOZ-AOHZEJALSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
701.778
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Polar area
|
266.43
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Complexity
|
1332.864752
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xlogp Value
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0.0265
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Heavy Count
|
50
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Rot Bonds
|
22
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Hbond acc
|
9
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker