Linker Information
General Information of This Linker
| Linker ID |
LIN0EQWAQ
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| Linker Name |
DBCO-6.4nnAA-B-Glucuronide-PEG12
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C76H110N6O26
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NC[C@H](NC(C1CC2(C1)CCN(C(CCCCC(N3C4=C(C#CC5=C(C=CC=C5)C3)C=CC=C4)=O)=O)CC2)=O)C(NCCC(NCC6=CC(CO)=CC=C6O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O7)=O)=O)=O
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| InChI |
InChI=1S/C76H110N6O26/c1-95-26-27-97-30-31-99-34-35-101-38-39-103-42-43-105-46-47-106-45-44-104-41-40-102-37-36-100-33-32-98-29-28-96-25-19-65(85)79-52-61(73(92)77-22-18-64(84)78-51-59-48-55(54-83)14-17-63(59)107-75-70(90)68(88)69(89)71(108-75)74(93)94)80-72(91)60-49-76(50-60)20-23-81(24-21-76)66(86)12-6-7-13-67(87)82-53-58-10-3-2-8-56(58)15-16-57-9-4-5-11-62(57)82/h2-5,8-11,14,17,48,60-61,68-71,75,83,88-90H,6-7,12-13,18-47,49-54H2,1H3,(H,77,92)(H,78,84)(H,79,85)(H,80,91)(H,93,94)/t61-,68-,69-,70+,71-,75+/m0/s1
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| InChIKey |
SWNNQWFYYXZSEV-NQVFOZIZSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1523.732
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Polar area
|
404.46
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Complexity
|
3134.182682
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xlogp Value
|
0.9183
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Heavy Count
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108
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Rot Bonds
|
55
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Hbond acc
|
25
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker