Linker Information
General Information of This Linker
| Linker ID |
LIN0EMJOT
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|---|---|---|---|---|---|---|
| Linker Name |
CN113549127A-ADC-19-linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H41N9O8S
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| Isosmiles |
OC([C@@H](NC(COCC(NCCOCCOCCN1C=C(N=N1)CCCN2C(C(C=NC(S)=N3)=C3C2)=O)=O)=O)CCCCN)=O
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| InChI |
InChI=1S/C27H41N9O8S/c28-6-2-1-5-21(26(40)41)31-24(38)18-44-17-23(37)29-7-10-42-12-13-43-11-9-36-15-19(33-34-36)4-3-8-35-16-22-20(25(35)39)14-30-27(45)32-22/h14-15,21H,1-13,16-18,28H2,(H,29,37)(H,31,38)(H,40,41)(H,30,32,45)/t21-/m0/s1
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| InChIKey |
MPAZOGQCNJRYCN-NRFANRHFSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
651.747
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Polar area
|
226.01
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Complexity
|
1198.376614
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xlogp Value
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-1.1902
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Heavy Count
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45
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Rot Bonds
|
23
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Hbond acc
|
14
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker