Linker Information
General Information of This Linker
| Linker ID |
LIN0EKFWP
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| Linker Name |
EP4487874A1-18linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C52H81N12O21P
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| Isosmiles |
CN(CC(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)=O)CC(N[C@H]2CCOC2=O)=O)=O)CCNC(CCOCCOCCOCCOCCNC([C@@H](N3C(C=CC3=O)=O)CNC(CCP(O)(O)=O)=O)=O)=O
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| InChI |
InChI=1S/C52H81N12O21P/c1-33(2)46(50(75)61-36(5-4-15-56-52(53)77)47(72)58-35-8-6-34(32-65)7-9-35)62-48(73)38(29-42(68)59-37-12-20-85-51(37)76)60-43(69)31-63(3)18-16-54-40(66)13-19-81-22-24-83-26-27-84-25-23-82-21-17-55-49(74)39(64-44(70)10-11-45(64)71)30-57-41(67)14-28-86(78,79)80/h6-11,33,36-39,46,65H,4-5,12-32H2,1-3H3,(H,54,66)(H,55,74)(H,57,67)(H,58,72)(H,59,68)(H,60,69)(H,61,75)(H,62,73)(H3,53,56,77)(H2,78,79,80)/t36-,37-,38-,39-,46-/m0/s1
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| InChIKey |
JIHVFESELYPJMW-BQEFHHQISA-N
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| Pharmaceutical Properties |
Molecule Weight
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1241.257
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Polar area
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469.52
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Complexity
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2397.397478
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xlogp Value
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-4.9036
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Heavy Count
|
86
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Rot Bonds
|
43
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Hbond acc
|
20
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker