Linker Information
General Information of This Linker
| Linker ID |
LIN0EJTEA
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|---|---|---|---|---|---|---|
| Linker Name |
aHer2- (AL11a-LP15)<sub>7.6</sub> Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C76H118N16O27
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| Isosmiles |
O=C(C)NCCOCCOCCOCCN(N=N1)C2=C1C(OCC(NCCOCCOCCOCCN(CC(NCCOCCOCCC(NCC(NCC(N[C@@H](CC3=CC=CC=C3)C(NCC(O)=O)=O)=O)=O)=O)=O)CC(NCCOCCOCCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)CCCCC2
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| InChI |
InChI=1S/C76H118N16O27/c1-56(93)77-19-27-111-37-41-118-44-40-116-32-24-92-61-15-9-4-10-16-62(74(61)89-90-92)119-55-71(102)80-22-30-114-38-42-117-43-39-115-31-23-91(53-69(100)78-20-28-112-35-33-109-25-17-63(94)81-47-65(96)83-49-67(98)87-59(75(107)85-51-72(103)104)45-57-11-5-2-6-12-57)54-70(101)79-21-29-113-36-34-110-26-18-64(95)82-48-66(97)84-50-68(99)88-60(76(108)86-52-73(105)106)46-58-13-7-3-8-14-58/h2-3,5-8,11-14,59-60,62H,4,9-10,15-55H2,1H3,(H,77,93)(H,78,100)(H,79,101)(H,80,102)(H,81,94)(H,82,95)(H,83,96)(H,84,97)(H,85,107)(H,86,108)(H,87,98)(H,88,99)(H,103,104)(H,105,106)/t59-,60-,62?/m0/s1
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| InChIKey |
TUBIQJHLVHZWSF-UATUTUMTSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1687.865
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Polar area
|
559.28
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Complexity
|
3189.766365
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xlogp Value
|
-5.4934
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Heavy Count
|
119
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Rot Bonds
|
69
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Hbond acc
|
29
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Hbond Donor
|
14
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Each Antibody-drug Conjugate Related to This Linker