Linker Information
General Information of This Linker
| Linker ID |
LIN0EJPOF
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| Linker Name |
COT-EDA- (GLCA)PAB linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C27H35N3O12
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| Isosmiles |
O=C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(C=C2C(NCCNC(COC3CCCCCC#C3)=O)=O)COC(N)=O)O1
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| InChI |
InChI=1S/C27H35N3O12/c28-27(38)40-13-15-8-9-18(41-26-22(34)20(32)21(33)23(42-26)25(36)37)17(12-15)24(35)30-11-10-29-19(31)14-39-16-6-4-2-1-3-5-7-16/h8-9,12,16,20-23,26,32-34H,1-4,6,10-11,13-14H2,(H2,28,38)(H,29,31)(H,30,35)(H,36,37)/t16?,20-,21-,22+,23-,26+/m0/s1
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| InChIKey |
ZISNOINTXSWBPY-IKSYRDBJSA-N
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| Pharmaceutical Properties |
Molecule Weight
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593.586
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Polar area
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236.2
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Complexity
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1132.304893
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xlogp Value
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-1.2484
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Heavy Count
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42
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Rot Bonds
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12
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Hbond acc
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11
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A- LP25-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.016 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 34% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
CTRL-ZP3A- LP25-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
80.211 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 35% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||