Linker Information
General Information of This Linker
| Linker ID |
LIN0EJLAI
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| Linker Name |
AU2023306656A1 ADC5 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C41H52N4O11S2
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| Isosmiles |
CC1=CC=C(S(CC(CS(C2=CC=C(C)C=C2)(=O)=O)C(C3=CC=C(C(N[C@@H](CCC(N[C@@H](C(C)C)C(N[C@@H](C)C=O)=O)=O)C(NCCOC)=O)=O)C=C3)=O)(=O)=O)C=C1
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| InChI |
InChI=1S/C41H52N4O11S2/c1-26(2)37(41(51)43-29(5)23-46)45-36(47)20-19-35(40(50)42-21-22-56-6)44-39(49)31-13-11-30(12-14-31)38(48)32(24-57(52,53)33-15-7-27(3)8-16-33)25-58(54,55)34-17-9-28(4)10-18-34/h7-18,23,26,29,32,35,37H,19-22,24-25H2,1-6H3,(H,42,50)(H,43,51)(H,44,49)(H,45,47)/t29-,35-,37-/m0/s1
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| InChIKey |
FHLDSSTVFHJNEH-UQVBKJIASA-N
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| Pharmaceutical Properties |
Molecule Weight
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841.018
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Polar area
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228.05
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Complexity
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1988.915796
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xlogp Value
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2.53574
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Heavy Count
|
58
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Rot Bonds
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22
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Hbond acc
|
11
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker