Linker Information
General Information of This Linker
| Linker ID |
LIN0EIZDA
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Anti-Her2-LP21 linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C53H88N12O18
|
|||||
| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1CC(NCCOCCOCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)CCCC2
|
|||||
| InChI |
InChI=1S/C53H88N12O18/c1-37(2)48(51(73)61-41(7-5-17-57-52(55)74)49(71)59-39-11-9-38(10-12-39)36-83-53(75)58-35-47(69)70)62-50(72)42(13-14-46(67)68)60-45(66)15-20-76-24-28-80-32-33-82-30-26-78-22-18-56-40-6-3-4-8-44-43(34-40)63-64-65(44)19-23-79-27-31-81-29-25-77-21-16-54/h9-12,37,40-42,48,56H,3-8,13-36,54H2,1-2H3,(H,58,75)(H,59,71)(H,60,66)(H,61,73)(H,62,72)(H,67,68)(H,69,70)(H3,55,57,74)/t40?,41-,42-,48-/m0/s1
|
|||||
| InChIKey |
ZMPIHJKUFJYPHF-GMGKZDHWSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1181.353
|
Polar area
|
417.82
|
||
|
Complexity
|
2118.054405
|
xlogp Value
|
-0.6566
|
|||
|
Heavy Count
|
83
|
Rot Bonds
|
46
|
|||
|
Hbond acc
|
21
|
Hbond Donor
|
11
|
|||
Each Antibody-drug Conjugate Related to This Linker