Linker Information
General Information of This Linker
| Linker ID |
LIN0EGWJU
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| Linker Name |
WO2023173026A1-ADC-L078-119-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H56N8O12
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(C1=CC=C(N)C(N)=C1)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(COC(O)=O)C=C2)=O)=O)C
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| InChI |
InChI=1S/C37H56N8O12/c1-24(2)32(35(49)44-30(4-3-12-42-36(40)50)34(48)43-27-8-5-25(6-9-27)23-57-37(51)52)45-31(46)11-14-53-16-18-55-20-21-56-19-17-54-15-13-41-33(47)26-7-10-28(38)29(39)22-26/h5-10,22,24,30,32H,3-4,11-21,23,38-39H2,1-2H3,(H,41,47)(H,43,48)(H,44,49)(H,45,46)(H,51,52)(H3,40,42,50)/t30-,32-/m0/s1
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| InChIKey |
ABQYGMUEZBHNAO-CDZUIXILSA-N
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| Pharmaceutical Properties |
Molecule Weight
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804.899
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Polar area
|
307.01
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Complexity
|
1505.509285
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xlogp Value
|
0.9447
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Heavy Count
|
57
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Rot Bonds
|
28
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Hbond acc
|
13
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker