Linker Information
General Information of This Linker
| Linker ID |
LIN0EGKGD
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Aminobenzazepine-linker Formula II-36
|
|||||
| Linker Type |
Unclear
|
|||||
| Antibody-Linker Relation |
Unclear
|
|||||
| Structure |
|
|||||
| Formula |
C12H10F4O6
|
|||||
| Isosmiles |
FC1=CC(F)=C(F)C(OC(CCOCCOC(O)=O)=O)=C1F
|
|||||
| InChI |
InChI=1S/C12H10F4O6/c13-6-5-7(14)10(16)11(9(6)15)22-8(17)1-2-20-3-4-21-12(18)19/h5H,1-4H2,(H,18,19)
|
|||||
| InChIKey |
RNZFXOWBKLKEFV-UHFFFAOYSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
326.198
|
Polar area
|
82.06
|
||
|
Complexity
|
505.2095591
|
xlogp Value
|
2.2497
|
|||
|
Heavy Count
|
22
|
Rot Bonds
|
7
|
|||
|
Hbond acc
|
5
|
Hbond Donor
|
1
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-24 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
|
||||
| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||