Linker Information
General Information of This Linker
| Linker ID |
LIN0EFICW
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| Linker Name |
BCN-GGGG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C19H26N4O7
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| Isosmiles |
OC(CNC(CNC(CNC(CNC(OC[C@H]1[C@@]2([H])CCC#CCC[C@]21[H])=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C19H26N4O7/c24-15(20-8-16(25)22-10-18(27)28)7-21-17(26)9-23-19(29)30-11-14-12-5-3-1-2-4-6-13(12)14/h12-14H,3-11H2,(H,20,24)(H,21,26)(H,22,25)(H,23,29)(H,27,28)/t12-,13+,14-
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| InChIKey |
LABQWSZOTACQTL-BTTYYORXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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422.438
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Polar area
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162.93
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Complexity
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686.05568
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xlogp Value
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-1.4146
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Heavy Count
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30
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Rot Bonds
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10
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Hbond acc
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6
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP6 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.04 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 12% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||