Linker Information
General Information of This Linker
| Linker ID |
LIN0EEQSS
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|---|---|---|---|---|---|---|
| Name |
Mal-Val-Lys (Ser-PEG4-glucose)-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C43H63N9O15
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| Isosmiles |
CC(C)[C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@H](CCCCNC([C@H](NC(CCOCC2=CN(N=N2)[C@@H](O3)[C@H](O)[C@@H](O)[C@H](O)[C@H]3CO)=O)CO)=O)C(NC4=CC=C(C=C4)CO)=O)=O
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| InChI |
InChI=1S/C43H63N9O15/c1-25(2)36(48-32(56)9-4-3-7-18-51-34(58)14-15-35(51)59)42(65)47-29(41(64)45-27-12-10-26(21-53)11-13-27)8-5-6-17-44-40(63)30(22-54)46-33(57)16-19-66-24-28-20-52(50-49-28)43-39(62)38(61)37(60)31(23-55)67-43/h10-15,20,25,29-31,36-39,43,53-55,60-62H,3-9,16-19,21-24H2,1-2H3,(H,44,63)(H,45,64)(H,46,57)(H,47,65)(H,48,56)/t29-,30-,31-,36-,37-,38+,39-,43+/m1/s1
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| InChIKey |
MSOCPFVGHWJIHW-FCDSOZPXSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
946.025
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Polar area
|
353.43
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Complexity
|
1892.668247
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xlogp Value
|
-2.8372
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Heavy Count
|
67
|
Rot Bonds
|
28
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Hbond acc
|
18
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker