Linker Information
General Information of This Linker
| Linker ID |
LIN0EDXRM
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| Linker Name |
CN119630431A-ADC-21-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C34H35N3O8S2
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| Isosmiles |
O=C(N1CCOCCOCCC(NCC(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)C(SC3=CC=CC=C3)=C(SC4=CC=CC=C4)C1=O
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| InChI |
InChI=1S/C34H35N3O8S2/c38-28(35-23-29(39)36-27(34(42)43)22-24-10-4-1-5-11-24)16-18-44-20-21-45-19-17-37-32(40)30(46-25-12-6-2-7-13-25)31(33(37)41)47-26-14-8-3-9-15-26/h1-15,27H,16-23H2,(H,35,38)(H,36,39)(H,42,43)/t27-/m0/s1
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| InChIKey |
BGHLUUHLJAPDLC-MHZLTWQESA-N
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| Pharmaceutical Properties |
Molecule Weight
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677.801
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Polar area
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151.34
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Complexity
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1434.477522
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xlogp Value
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3.503
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Heavy Count
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47
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Rot Bonds
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19
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Hbond acc
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9
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Hbond Donor
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3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 10 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.036 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||