Linker Information
General Information of This Linker
| Linker ID |
LIN0EDMZI
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| Linker Name |
BGA7413 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C23H28N4O11S
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| Isosmiles |
CC([C@H](NC(C1=CC=C(C2=NSC=N2)C=C1)=O)C(N[C@@H](CO[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O3)C(O)=O)=O)C
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| InChI |
InChI=1S/C23H28N4O11S/c1-9(2)13(26-19(31)11-5-3-10(4-6-11)18-24-8-39-27-18)20(32)25-12(21(33)34)7-37-23-16(30)14(28)15(29)17(38-23)22(35)36/h3-6,8-9,12-17,23,28-30H,7H2,1-2H3,(H,25,32)(H,26,31)(H,33,34)(H,35,36)/t12-,13-,14-,15-,16+,17-,23+/m0/s1
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| InChIKey |
UVQNJEUCNMSWKM-DEVNHDCCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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568.561
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Polar area
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237.73
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Complexity
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1105.297973
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xlogp Value
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-1.5623
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Heavy Count
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39
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Rot Bonds
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11
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Hbond acc
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12
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
BGA7413 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.16 nM
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Positive CEA expression (CEA+++/++) | ||
| Method Description |
NCI-H2122 cells were plated at a density of 2000 cells per well and the next day were treated with payload compounds (5x dilution) for 6 days.
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| In Vitro Model | Lung adenocarcinoma | NCI-H2122 cells | CVCL_1531 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.46 nM
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Positive CEA expression (CEA+++/++) | ||
| Method Description |
MKN45 cells were plated at a density of 5000 cells per well and the next day were treated with payload compounds (5x dilution) for 6 days.
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| In Vitro Model | Gastric adenocarcinoma | MKN45 cells | CVCL_0434 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.88 nM
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Positive CEA expression (CEA+++/++) | ||
| Method Description |
Ls147T cells were plated at a density of 5000 cells per well and the next day were treated with payload compounds (5x dilution) for 6 days.
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| In Vitro Model | Colon adenocarcinoma | Ls147T cells | CVCL_1384 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
28 nM
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Negative CEA expression (CEA-) | ||
| Method Description |
MDA-MB-231 cells were plated at a density of 2000 cells per well and the next day were treated with payload compounds (5x dilution) for 6 days.
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-231 cells | CVCL_0062 | ||