Linker Information
General Information of This Linker
| Linker ID |
LIN0EAJJL
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| Linker Name |
TetraDVP based linker 1a
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C132H191N33O25
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| Isosmiles |
O=C(NCCC(N1C(C=CC=C2)=C2C(N=NN3CCOCCOCCOCCOCCOCCC(NCCCNC(CN(CCNC(CN(CCNC(CCCNC4=NC(C=C)=CC(C=C)=N4)=O)CCNC(CCCNC5=NC(C=C)=CC(C=C)=N5)=O)=O)CCNC(CN(CCNC(CCCNC6=NC(C=C)=CC(C=C)=N6)=O)CCNC(CCCNC7=NC(C=C)=CC(C=C)=N7)=O)=O)=O)=O)=C3C(C=CC=C8)=C8C1)=O)CCOCCOCCOCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC9=CC=C(C=C9)CO)=O)=O)C(C)C)=O
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| InChI |
InChI=1S/C132H191N33O25/c1-11-99-87-100(12-2)150-129(149-99)144-47-24-34-112(167)137-54-60-161(61-55-138-113(168)35-25-48-145-130-151-101(13-3)88-102(14-4)152-130)93-120(175)141-58-64-163(65-59-142-121(176)94-162(62-56-139-114(169)36-26-49-146-131-153-103(15-5)89-104(16-6)154-131)63-57-140-115(170)37-27-50-147-132-155-105(17-7)90-106(18-8)156-132)92-119(174)135-52-28-51-134-116(171)43-67-181-71-75-185-80-84-190-86-82-188-78-74-184-70-66-165-125-108-30-20-19-29-98(108)91-164(111-33-22-21-31-109(111)124(125)159-160-165)122(177)42-53-136-117(172)44-68-182-72-76-186-79-83-189-85-81-187-77-73-183-69-45-118(173)158-123(96(9)10)127(179)157-110(32-23-46-143-128(133)180)126(178)148-107-40-38-97(95-166)39-41-107/h11-22,29-31,33,38-41,87-90,96,110,123,166H,1-8,23-28,32,34-37,42-86,91-95H2,9-10H3,(H,134,171)(H,135,174)(H,136,172)(H,137,167)(H,138,168)(H,139,169)(H,140,170)(H,141,175)(H,142,176)(H,148,178)(H,157,179)(H,158,173)(H3,133,143,180)(H,144,149,150)(H,145,151,152)(H,146,153,154)(H,147,155,156)/t110-,123-/m0/s1
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| InChIKey |
LEMYQVBMAAFQKG-GBYSWQTFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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2640.186
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Polar area
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728.83
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Complexity
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.
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xlogp Value
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5.6053
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Heavy Count
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190
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Rot Bonds
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106
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Hbond acc
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43
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Hbond Donor
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19
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Each Antibody-drug Conjugate Related to This Linker
