Linker Information
General Information of This Linker
| Linker ID |
LIN0EAAPL
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| Linker Name |
Ab-MC-VC-PAB-DMEDA-PEG (N3)-SN38 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H56N8O12
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| Isosmiles |
CC([C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(COC(N(C)CCN(C(O)=O)CCOCCO)=O)C=C2)=O)=O)C
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| InChI |
InChI=1S/C37H56N8O12/c1-25(2)32(42-29(47)9-5-4-6-17-45-30(48)14-15-31(45)49)34(51)41-28(8-7-16-39-35(38)52)33(50)40-27-12-10-26(11-13-27)24-57-37(55)43(3)18-19-44(36(53)54)20-22-56-23-21-46/h10-15,25,28,32,46H,4-9,16-24H2,1-3H3,(H,40,50)(H,41,51)(H,42,47)(H,53,54)(H3,38,39,52)/t28-,32-/m0/s1
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| InChIKey |
JBKBHOSWSOWSGJ-IUDBTDONSA-N
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| Pharmaceutical Properties |
Molecule Weight
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804.899
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Polar area
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279.34
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Complexity
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1464.391994
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xlogp Value
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0.7419
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Heavy Count
|
57
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Rot Bonds
|
26
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Hbond acc
|
11
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker