Linker Information
General Information of This Linker
| Linker ID |
LIN0DYSGZ
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|---|---|---|---|---|---|---|
| Linker Name |
PY-MAA-Val-Cit-PABC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C32H46N8O8S
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| Isosmiles |
C=CC(=O)N1CN(C(=O)C=C)CN(C(=O)CCSCC(=O)NC(C(=O)NC(CCCNC(N)=O)C(=O)Nc2ccc(CO)cc2)C(C)C)C1
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| InChI |
InChI=1S/C32H46N8O8S/c1-5-26(43)38-18-39(27(44)6-2)20-40(19-38)28(45)13-15-49-17-25(42)37-29(21(3)4)31(47)36-24(8-7-14-34-32(33)48)30(46)35-23-11-9-22(16-41)10-12-23/h5-6,9-12,21,24,29,41H,1-2,7-8,13-20H2,3-4H3,(H,35,46)(H,36,47)(H,37,42)(H3,33,34,48)
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| InChIKey |
HQIKSJQCJBQAKX-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
702.835
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Polar area
|
223.58
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Complexity
|
49
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xlogp Value
|
0.0587
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Heavy Count
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49
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Rot Bonds
|
18
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Hbond acc
|
9
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Hbond Donor
|
6
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Each Antibody-drug Conjugate Related to This Linker
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