Linker Information
General Information of This Linker
| Linker ID |
LIN0DWRAJ
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| Linker Name |
LA2 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C31H40N6O10
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| Isosmiles |
O=C(N1CCCCCC(NCC(NCC(N[C@H](C(NCC(NCO[C@@H](C2CC2)C(O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)C=CC1=O
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| PubChem CID | ||||||
| InChI |
InChI=1S/C31H40N6O10/c38-23(9-5-2-6-14-37-27(42)12-13-28(37)43)32-16-24(39)33-18-26(41)36-22(15-20-7-3-1-4-8-20)30(44)34-17-25(40)35-19-47-29(31(45)46)21-10-11-21/h1,3-4,7-8,12-13,21-22,29H,2,5-6,9-11,14-19H2,(H,32,38)(H,33,39)(H,34,44)(H,35,40)(H,36,41)(H,45,46)/t22-,29-/m0/s1
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| InChIKey |
SHKYFEZQVRQXHQ-ZTOMLWHTSA-N
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| Pharmaceutical Properties |
Molecule Weight
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656.693
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Polar area
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229.41
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Complexity
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1270.503054
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xlogp Value
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-1.4986
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Heavy Count
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47
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Rot Bonds
|
21
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Hbond acc
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9
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Hbond Donor
|
6
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Each Antibody-drug Conjugate Related to This Linker