Linker Information
General Information of This Linker
| Linker ID |
LIN0DUXXM
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| Linker Name |
CN119630431A-ADC-34-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C30H34N4O10S2
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| Isosmiles |
O=C(N)C[C@H](NC([C@@H](NC(CCOCCOCCN1C(C(SC2=CC=CC=C2)=C(SC3=CC=CC=C3)C1=O)=O)=O)CO)=O)C(O)=O
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| InChI |
InChI=1S/C30H34N4O10S2/c31-23(36)17-21(30(41)42)33-27(38)22(18-35)32-24(37)11-13-43-15-16-44-14-12-34-28(39)25(45-19-7-3-1-4-8-19)26(29(34)40)46-20-9-5-2-6-10-20/h1-10,21-22,35H,11-18H2,(H2,31,36)(H,32,37)(H,33,38)(H,41,42)/t21-,22-/m0/s1
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| InChIKey |
ZHNQSSCRIPAQBK-VXKWHMMOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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674.754
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Polar area
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214.66
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Complexity
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1298.131381
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xlogp Value
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0.4966
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Heavy Count
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46
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Rot Bonds
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20
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Hbond acc
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11
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 23 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.034 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||