Linker Information
General Information of This Linker
| Linker ID |
LIN0DSPIB
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|---|---|---|---|---|---|---|
| Linker Name |
aHer2- (AL6-LP1)<sub>3.6</sub> Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C50H73N9O12
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(COC1CCCCCC2=C1C=NN=C2C3=CC=C(C=C3)CNC(C)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)CO)=O)=O)C
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| InChI |
InChI=1S/C50H73N9O12/c1-34(2)46(49(65)57-42(9-7-20-53-50(51)66)48(64)56-39-17-13-37(32-60)14-18-39)58-44(62)19-22-67-24-26-69-28-29-70-27-25-68-23-21-52-45(63)33-71-43-10-6-4-5-8-40-41(43)31-55-59-47(40)38-15-11-36(12-16-38)30-54-35(3)61/h11-18,31,34,42-43,46,60H,4-10,19-30,32-33H2,1-3H3,(H,52,63)(H,54,61)(H,56,64)(H,57,65)(H,58,62)(H3,51,53,66)/t42-,43?,46-/m0/s1
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| InChIKey |
BBHFBMKBXLOWBV-ACFZIETLSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
992.185
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Polar area
|
292.78
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Complexity
|
2027.710207
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xlogp Value
|
2.7317
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Heavy Count
|
71
|
Rot Bonds
|
32
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Hbond acc
|
14
|
Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker