Linker Information
General Information of This Linker
| Linker ID |
LIN0DSGXX
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| Linker Name |
CN119326907A Trastuzumab-GDP-D-P1/P1-C2-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C63H89N17O22
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| Isosmiles |
O=C(NCC(O)=O)[C@@H](NC(CNC(CNC(CCCC1=CN(N=N1)CCOCCN(CCNC(CCC(NC[C@H](O2)[C@@H](O)[C@H]([C@H](O)[C@H]2O)O)=O)=O)C(CCOCCN3C=C(N=N3)CCCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5
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| InChI |
InChI=1S/C63H89N17O22/c81-47(66-32-51(85)68-34-53(87)72-44(61(97)70-36-56(90)91)29-40-9-3-1-4-10-40)15-7-13-42-38-79(76-74-42)23-27-100-25-19-55(89)78(21-20-64-49(83)17-18-50(84)65-31-46-58(94)59(95)60(96)63(99)102-46)22-26-101-28-24-80-39-43(75-77-80)14-8-16-48(82)67-33-52(86)69-35-54(88)73-45(62(98)71-37-57(92)93)30-41-11-5-2-6-12-41/h1-6,9-12,38-39,44-46,58-60,63,94-96,99H,7-8,13-37H2,(H,64,83)(H,65,84)(H,66,81)(H,67,82)(H,68,85)(H,69,86)(H,70,97)(H,71,98)(H,72,87)(H,73,88)(H,90,91)(H,92,93)/t44-,45-,46-,58+,59+,60-,63-/m0/s1
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| InChIKey |
XHGLADJTJWEJLO-RLAQNCLVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1436.502
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Polar area
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555.94
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Complexity
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3245.056786
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xlogp Value
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-7.399
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Heavy Count
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102
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Rot Bonds
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48
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Hbond acc
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26
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Hbond Donor
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16
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Each Antibody-drug Conjugate Related to This Linker