Linker Information
General Information of This Linker
| Linker ID |
LIN0DPUYU
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
WO2022099762A1 10
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C35H52N8O11S
|
|||||
| Isosmiles |
CCCCNC(CCCCCN1C(CC(SC[C@H](N)C(NCC(NCC(N[C@H](C(NCC(NCOCC(O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)C1=O)=O)=O
|
|||||
| InChI |
InChI=1S/C35H52N8O11S/c1-2-3-13-37-27(44)12-8-5-9-14-43-31(48)16-26(35(43)53)55-21-24(36)33(51)39-17-28(45)38-19-30(47)42-25(15-23-10-6-4-7-11-23)34(52)40-18-29(46)41-22-54-20-32(49)50/h4,6-7,10-11,24-26H,2-3,5,8-9,12-22,36H2,1H3,(H,37,44)(H,38,45)(H,39,51)(H,40,52)(H,41,46)(H,42,47)(H,49,50)/t24-,25-,26?/m0/s1
|
|||||
| InChIKey |
XMQROBMMWYQURE-NPGWBMRXSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
792.913
|
Polar area
|
284.53
|
||
|
Complexity
|
1406.74453
|
xlogp Value
|
-2.0979
|
|||
|
Heavy Count
|
55
|
Rot Bonds
|
27
|
|||
|
Hbond acc
|
12
|
Hbond Donor
|
8
|
|||
Each Antibody-drug Conjugate Related to This Linker