Linker Information
General Information of This Linker
| Linker ID |
LIN0DPQRI
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| Linker Name |
EP4487874A1-19linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C46H70N10O22P2
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| Isosmiles |
CC(C)[C@H](NC([C@@H](NC(CCOCCOCCOCP(OCCNC([C@@H](N1C(C=CC1=O)=O)CNC(CCP(O)(O)=O)=O)=O)(O)=O)=O)CC(N[C@H]2CCOC2=O)=O)=O)C(N[C@H](C(NC3=CC=C(CO)C=C3)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C46H70N10O22P2/c1-28(2)40(44(66)54-31(4-3-14-49-46(47)68)41(63)51-30-7-5-29(26-57)6-8-30)55-42(64)33(24-37(60)52-32-11-17-77-45(32)67)53-36(59)12-16-74-19-20-75-21-22-76-27-80(72,73)78-18-15-48-43(65)34(56-38(61)9-10-39(56)62)25-50-35(58)13-23-79(69,70)71/h5-10,28,31-34,40,57H,3-4,11-27H2,1-2H3,(H,48,65)(H,50,58)(H,51,63)(H,52,60)(H,53,59)(H,54,66)(H,55,64)(H,72,73)(H3,47,49,68)(H2,69,70,71)/t31-,32-,33-,34-,40-/m0/s1
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| InChIKey |
ZWFDJVQAUOYPBW-IKKRJENISA-N
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| Pharmaceutical Properties |
Molecule Weight
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1177.062
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Polar area
|
474.48
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Complexity
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2324.734839
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xlogp Value
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-3.8087
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Heavy Count
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80
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Rot Bonds
|
38
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Hbond acc
|
19
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker