Linker Information
General Information of This Linker
| Linker ID |
LIN0DFVHV
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| Linker Name |
TW202506738A-C-155-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C92H143N14O27
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| Isosmiles |
C[C@H](NC(CCCNC([C@@H](NC(CCN(N(CCC(N[C@H](C(NCCCC(N[C@H](C(NC1=CC=C(C)C=C1)=O)C)=O)=O)CCCCNC(COCCOCOCOCOCOCOCOCOC)=O)=O)C(CCCN2C(C=CC2=O)=O)=O)C(CCCN3C(C=CC3=O)=O)=O)=O)CCCCNC(COCCCCCCCCCCCCCCCC[O])=O)=O)=O)C(NC4=CC=C(C)C=C4)=O
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| InChI |
InChI=1S/C92H143N14O27/c1-69-34-38-73(39-35-69)99-89(120)71(3)97-77(108)30-24-50-95-91(122)75(28-18-20-48-93-81(112)60-125-57-23-17-15-13-11-9-7-6-8-10-12-14-16-22-56-107)101-79(110)46-54-105(87(118)32-26-52-103-83(114)42-43-84(103)115)106(88(119)33-27-53-104-85(116)44-45-86(104)117)55-47-80(111)102-76(92(123)96-51-25-31-78(109)98-72(4)90(121)100-74-40-36-70(2)37-41-74)29-19-21-49-94-82(113)61-126-58-59-127-63-129-65-131-67-133-68-132-66-130-64-128-62-124-5/h34-45,71-72,75-76H,6-33,46-68H2,1-5H3,(H,93,112)(H,94,113)(H,95,122)(H,96,123)(H,97,108)(H,98,109)(H,99,120)(H,100,121)(H,101,110)(H,102,111)/t71-,72-,75-,76-/m0/s1
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| InChIKey |
IIAJCGASDVZEBC-UMEAJEHRSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1877.227
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Polar area
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518.58
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Complexity
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.
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xlogp Value
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5.37844
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Heavy Count
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133
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Rot Bonds
|
79
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Hbond acc
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26
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker