Linker Information
General Information of This Linker
| Linker ID |
LIN0DCONU
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| Linker Name |
NH2-PEG4-EvcPAB-NHCH2
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C36H60N8O14
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCOCCOCCOCCOCCN)=O)CCC(O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)COC(NCO)=O)=O)=O)C
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| InChI |
InChI=1S/C36H60N8O14/c1-24(2)31(44-33(50)28(9-10-30(47)48)42-29(46)11-14-54-16-18-56-20-21-57-19-17-55-15-12-37)34(51)43-27(4-3-13-39-35(38)52)32(49)41-26-7-5-25(6-8-26)22-58-36(53)40-23-45/h5-8,24,27-28,31,45H,3-4,9-23,37H2,1-2H3,(H,40,53)(H,41,49)(H,42,46)(H,43,51)(H,44,50)(H,47,48)(H3,38,39,52)/t27-,28-,31-/m0/s1
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| InChIKey |
VEIMBPIMLXTDGH-QYDYLWNGSA-N
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| Pharmaceutical Properties |
Molecule Weight
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828.918
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Polar area
|
330.32
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Complexity
|
1326.250834
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xlogp Value
|
-1.36
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Heavy Count
|
58
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Rot Bonds
|
32
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Hbond acc
|
14
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker