Linker Information
General Information of This Linker
| Linker ID |
LIN0DBCFQ
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| Linker Name |
DIBAC-PEG4-EvcPAB-Gly linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C56H73N9O17
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| Isosmiles |
O=C(NCC(O)=O)OCC(C=C1)=CC=C1NC([C@@H](NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(CCC(N2C3=C(C#CC4=C(C=CC=C4)C2)C=CC=C3)=O)=O)=O)CCC(O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C56H73N9O17/c1-37(2)51(54(75)63-43(11-7-24-59-55(57)76)52(73)61-42-17-13-38(14-18-42)36-82-56(77)60-34-50(71)72)64-53(74)44(19-22-49(69)70)62-47(67)23-26-78-28-30-80-32-33-81-31-29-79-27-25-58-46(66)20-21-48(68)65-35-41-10-4-3-8-39(41)15-16-40-9-5-6-12-45(40)65/h3-6,8-10,12-14,17-18,37,43-44,51H,7,11,19-36H2,1-2H3,(H,58,66)(H,60,77)(H,61,73)(H,62,67)(H,63,75)(H,64,74)(H,69,70)(H,71,72)(H3,57,59,76)/t43-,44-,51-/m0/s1
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| InChIKey |
YGWYCTIOZGQHIH-DNAHZZCBSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1144.246
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Polar area
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370.78
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Complexity
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2597.541533
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xlogp Value
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1.6591
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Heavy Count
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82
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Rot Bonds
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37
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Hbond acc
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15
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Hbond Donor
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10
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP26 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.078 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 20% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
CTRL-ZP3A-LP26 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
58.334 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 21% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||