Linker Information
General Information of This Linker
| Linker ID |
LIN0CZUEK
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| Linker Name |
PSMA-HC41-LD36 LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C20H35N5O5
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| Isosmiles |
CC(C(N(C)C)C(N[C@@H](C)C(NCCNCCOCCN1C(C=CC1=O)=O)=O)=O)C
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| InChI |
InChI=1S/C20H35N5O5/c1-14(2)18(24(4)5)20(29)23-15(3)19(28)22-9-8-21-10-12-30-13-11-25-16(26)6-7-17(25)27/h6-7,14-15,18,21H,8-13H2,1-5H3,(H,22,28)(H,23,29)/t15-,18?/m0/s1
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| InChIKey |
WDIZKSVEQJHYQM-BUSXIPJBSA-N
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| Pharmaceutical Properties |
Molecule Weight
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425.53
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Polar area
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120.08
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Complexity
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571.5278502
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xlogp Value
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-1.2753
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Heavy Count
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30
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Rot Bonds
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14
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Hbond acc
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7
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Hbond Donor
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3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
PSMA-HC41-LD36 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
100 nM
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Positive PSMA expression (PSMA +++/++) | ||
| Method Description |
In vitro cytotoxicity of anti-PSMA ADCs in human tumour cells expressing PSMAPSMA-positive cell line LNCaP-C4.2
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| In Vitro Model | Prostate carcinoma | LNCaP-C4.2 cells | CVCL_4782 | ||