General Information of This Linker
Linker ID
LIN0CZEKQ
Linker Name
Anti-Her2-AL1- LP26 linker
Linker Type
Cathepsin-cleavable linker
Antibody-Linker Relation
Cleavable
Structure
Formula
C115H168FN23O36
Isosmiles
NCCOCCOCCOCCN(N=N1)C2=C1CC(C(CCC(N(CC(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(NCOCC(N[C@H]4CCC5=C6C4=C7CN(C(C7NC6=CC(F)=C5C)=C8)C(C(CO9)=C8[C@](CC)(O)C9=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)=O)CC(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC%10=CC=C(C=C%10)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)=O)CCCC2
InChI
InChI=1S/C115H168FN23O36/c1-7-115(160)82-59-90-104-80(63-138(90)109(154)81(82)68-173-110(115)155)101-84(25-24-79-73(6)83(116)60-88(130-104)100(79)101)129-97(146)69-172-70-126-94(143)61-124-113(158)174-66-74-16-20-77(21-17-74)127-105(150)85(13-10-31-122-111(118)156)131-107(152)102(71(2)3)133-92(141)28-36-161-42-48-167-54-56-170-51-45-164-39-33-120-95(144)64-137(98(147)27-26-91(140)76-12-8-9-15-89-87(58-76)135-136-139(89)35-41-166-47-53-169-50-44-163-38-30-117)65-96(145)121-34-40-165-46-52-171-57-55-168-49-43-162-37-29-93(142)134-103(72(4)5)108(153)132-86(14-11-32-123-112(119)157)106(151)128-78-22-18-75(19-23-78)67-175-114(159)125-62-99(148)149/h16-23,59-60,71-72,76,84-86,102-104,130,160H,7-15,24-58,61-70,117H2,1-6H3,(H,120,144)(H,121,145)(H,124,158)(H,125,159)(H,126,143)(H,127,150)(H,128,151)(H,129,146)(H,131,152)(H,132,153)(H,133,141)(H,134,142)(H,148,149)(H3,118,122,156)(H3,119,123,157)/t76?,84-,85-,86-,102-,103-,104?,115-/m0/s1
InChIKey
LXGDSFJXWWHZGJ-QKQNDPPXSA-N
Pharmaceutical Properties
Molecule Weight
2467.732
Polar area
800.63
Complexity
.
xlogp Value
-0.12328
Heavy Count
175
Rot Bonds
83
Hbond acc
41
Hbond Donor
20
Each Antibody-drug Conjugate Related to This Linker