Linker Information
General Information of This Linker
| Linker ID |
LIN0CUUAJ
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| Linker Name |
CN116916962A-C-39-linker
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C45H72N6O16
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](CCCCNC(CN1C(C=CC1=O)=O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(NC2=CC=C(CO)C=C2)=O)=O)=O)=O
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| InChI |
InChI=1S/C45H72N6O16/c1-33(2)42(45(59)47-34(3)43(57)48-36-10-8-35(32-52)9-11-36)50-44(58)37(7-5-6-15-46-39(54)31-51-40(55)12-13-41(51)56)49-38(53)14-16-61-19-20-63-23-24-65-27-28-67-30-29-66-26-25-64-22-21-62-18-17-60-4/h8-13,33-34,37,42,52H,5-7,14-32H2,1-4H3,(H,46,54)(H,47,59)(H,48,57)(H,49,53)(H,50,58)/t34-,37-,42-/m0/s1
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| InChIKey |
LVOFCCISEQXIJN-LKYDRFQPSA-N
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| Pharmaceutical Properties |
Molecule Weight
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953.097
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Polar area
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276.95
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Complexity
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1551.428701
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xlogp Value
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-0.3881
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Heavy Count
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67
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Rot Bonds
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40
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Hbond acc
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16
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN116916962A-ADC-B19 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
3.09 nM
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High hCCR2 expression (hCCR2+++) | ||
| Method Description |
THP 1, 15,000cells/254uL per welld were plated at set in 384 well flat plate, in the appropriate growth media. The cell plates were dosed with 5uL of the hCCR2 targeting-ADC samples and then incubated at 37°C for 20 hours. At the end of the incubation 10uL/well of the QUANTJ-LucTM (InvivoGenftrep-qlc1) were added and luminescence was measured immediately using the LeadSeeker.
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP1 cells | CVCL_0006 | ||