Linker Information
General Information of This Linker
| Linker ID |
LIN0CUSIA
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|---|---|---|---|---|---|---|
| Linker Name |
IG-L-14 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C61H92N14O24
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| Isosmiles |
C[C@H](NC([C@H](C)NC(C)=O)=O)C(NC1=CC=C(C(OC(O)=O)CN(N=N2)C=C2CC[C@H](NC(COCCOCCNC(CCN3C(C=CC3=O)=O)=O)=O)C(N(CCOCC(N(CCOCC(N(CCOCC(N(CCOCC(N(CCOCC(O)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C=C1)=O
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| InChI |
InChI=1S/C61H92N14O24/c1-41(63-43(3)76)58(87)64-42(2)59(88)65-45-11-9-44(10-12-45)48(99-61(90)91)34-74-33-46(67-68-74)13-14-47(66-50(78)35-98-32-31-92-25-18-62-49(77)17-19-75-51(79)15-16-52(75)80)60(89)73(8)24-30-96-39-56(84)71(6)22-28-94-37-54(82)69(4)20-26-93-36-53(81)70(5)21-27-95-38-55(83)72(7)23-29-97-40-57(85)86/h9-12,15-16,33,41-42,47-48H,13-14,17-32,34-40H2,1-8H3,(H,62,77)(H,63,76)(H,64,87)(H,65,88)(H,66,78)(H,85,86)(H,90,91)/t41-,42-,47-,48?/m0/s1
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| InChIKey |
CGHVPCPGAVTOEI-MWPUQESKSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1405.481
|
Polar area
|
463.58
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Complexity
|
2893.569158
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xlogp Value
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-3.9767
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Heavy Count
|
99
|
Rot Bonds
|
50
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Hbond acc
|
25
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker