Linker Information

General Information of This Linker
Linker ID
LIN0CUBTI
Linker Name
Mal-EBE-Mal
Linker Type
Uncleavable linker
Antibody-Linker Relation
Uncleavable
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
Glypican 3 ADC [Phase 1]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI)
100%
Positive GPC3 expression (GPC3+++/++)
Method Description
Female NOD/SCID mice were inoculated subcutaneously in the right flank with 500,000 Hep3B cells. Three weekly administration of A2-tub at 0.12 mol/kg.
In Vivo Model Hep3B CDX model
In Vitro Model Childhood hepatocellular carcinoma Hep 3B2.1-7 cells CVCL_0326
References
Ref 1 Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors. Protein Eng Des Sel. 2018 May 1;31(5):159-171. doi: 10.1093/protein/gzy013.