Linker Information
General Information of This Linker
| Linker ID |
LIN0CTRJB
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN119630431A-ADC-28-LINKER
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C36H37N5O9S2
|
|||||
| Isosmiles |
O=C(CNC(CNC(CCOCCN(C1=O)C(C(SC2=CC=CC=C2)=C1SC3=CC=CC=C3)=O)=O)=O)N[C@H](C(NCC(O)=O)=O)CC4=CC=CC=C4
|
|||||
| InChI |
InChI=1S/C36H37N5O9S2/c42-28(37-21-29(43)38-22-30(44)40-27(34(47)39-23-31(45)46)20-24-10-4-1-5-11-24)16-18-50-19-17-41-35(48)32(51-25-12-6-2-7-13-25)33(36(41)49)52-26-14-8-3-9-15-26/h1-15,27H,16-23H2,(H,37,42)(H,38,43)(H,39,47)(H,40,44)(H,45,46)/t27-/m0/s1
|
|||||
| InChIKey |
NTKAJQVENIYLMT-MHZLTWQESA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
747.852
|
Polar area
|
200.31
|
||
|
Complexity
|
1644.703734
|
xlogp Value
|
1.7188
|
|||
|
Heavy Count
|
52
|
Rot Bonds
|
20
|
|||
|
Hbond acc
|
10
|
Hbond Donor
|
5
|
|||
Each Antibody-drug Conjugate Related to This Linker