Linker Information
General Information of This Linker
| Linker ID |
LIN0CPFWS
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|---|---|---|---|---|---|---|
| Linker Name |
Mal-Val-Cit-gucuronide-PEG8-PABC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C47H74N4O19
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C1OC(CCc2cc(NC(=O)C(C)NC(=O)C(CC(=O)CN3C(=O)C=CC3=O)C(C)C)ccc2CO)C(O)C(O)C1O
|
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| InChI |
InChI=1S/C47H74N4O19/c1-31(2)37(28-36(53)29-51-39(54)9-10-40(51)55)46(60)49-32(3)45(59)50-35-7-5-34(30-52)33(27-35)6-8-38-41(56)42(57)43(58)44(70-38)47(61)48-11-12-63-15-16-65-19-20-67-23-24-69-26-25-68-22-21-66-18-17-64-14-13-62-4/h5,7,9-10,27,31-32,37-38,41-44,52,56-58H,6,8,11-26,28-30H2,1-4H3,(H,48,61)(H,49,60)(H,50,59)
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| InChIKey |
QRJRVSXQMWSYRX-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
999.118
|
Polar area
|
305.74
|
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Complexity
|
70
|
xlogp Value
|
-1.56
|
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Heavy Count
|
70
|
Rot Bonds
|
38
|
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|
Hbond acc
|
19
|
Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker
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