Linker Information
General Information of This Linker
| Linker ID |
LIN0CMJSR
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| Linker Name |
DBCO SIDECHAIN PEG12-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C68H98N6O23
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NC[C@H](NC(CCCCC(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)=O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(NC4=CC=C(OCC(O)=O)C=C4)=O)CCC(O)=O)=O)=O)=O
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| InChI |
InChI=1S/C68H98N6O23/c1-51(2)65(68(84)72-57(22-23-63(78)79)66(82)70-55-18-20-56(21-19-55)97-50-64(80)81)73-67(83)58(71-61(76)14-8-9-15-62(77)74-49-54-12-5-4-10-52(54)16-17-53-11-6-7-13-59(53)74)48-69-60(75)24-25-86-28-29-88-32-33-90-36-37-92-40-41-94-44-45-96-47-46-95-43-42-93-39-38-91-35-34-89-31-30-87-27-26-85-3/h4-7,10-13,18-21,51,57-58,65H,8-9,14-15,22-50H2,1-3H3,(H,69,75)(H,70,82)(H,71,76)(H,72,84)(H,73,83)(H,78,79)(H,80,81)/t57-,58-,65-/m0/s1
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| InChIKey |
IDMBYRZCNXUCLU-LOPMFALUSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1367.551
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Polar area
|
360.4
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Complexity
|
2731.150083
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xlogp Value
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2.906
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Heavy Count
|
97
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Rot Bonds
|
57
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Hbond acc
|
21
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker