General Information of This Linker
Linker ID
LIN0CLBJX
Linker Name
Anti-Her2-AL1- LP37 linker
Linker Type
Cathepsin-cleavable linker
Antibody-Linker Relation
Cleavable
Structure
Formula
C93H147N21O35
Isosmiles
NCCOCCOCCOCCN(N=N1)C2=C1C(OCC(NC(COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(NC(C=C4)=CC=C4COC(NCC(O)=O)=O)=O)CCCNC(N)=O)=O)C(C)C)=O)=O)=O)=O)CCCCC2
InChI
InChI=1S/C93H147N21O35/c1-59(2)81(88(132)108-66(10-8-31-99-90(95)134)84(128)104-63-18-14-61(15-19-63)54-148-92(136)101-52-79(124)125)110-86(130)68(22-24-77(120)121)106-74(117)28-36-138-44-47-141-41-33-97-72(115)26-38-145-56-65(103-76(119)58-147-71-13-7-5-6-12-70-83(71)112-113-114(70)35-43-143-49-51-144-50-46-140-40-30-94)57-146-39-27-73(116)98-34-42-142-48-45-139-37-29-75(118)107-69(23-25-78(122)123)87(131)111-82(60(3)4)89(133)109-67(11-9-32-100-91(96)135)85(129)105-64-20-16-62(17-21-64)55-149-93(137)102-53-80(126)127/h14-21,59-60,65-69,71,81-82H,5-13,22-58,94H2,1-4H3,(H,97,115)(H,98,116)(H,101,136)(H,102,137)(H,103,119)(H,104,128)(H,105,129)(H,106,117)(H,107,118)(H,108,132)(H,109,133)(H,110,130)(H,111,131)(H,120,121)(H,122,123)(H,124,125)(H,126,127)(H3,95,99,134)(H3,96,100,135)/t66-,67-,68-,69-,71?,81-,82-/m0/s1
InChIKey
MPOTZPVZLTVZMH-QQNKBTHPSA-N
Pharmaceutical Properties
Molecule Weight
2119.311
Polar area
805.23
Complexity
.
xlogp Value
-2.4156
Heavy Count
149
Rot Bonds
81
Hbond acc
35
Hbond Donor
22
Each Antibody-drug Conjugate Related to This Linker