Linker Information
General Information of This Linker
| Linker ID |
LIN0CKKUQ
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| Linker Name |
Mal-Exo-EEVC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C40H57N9O15
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| Isosmiles |
CC(C)[C@H](NC([C@@H](NCC(N[C@@H](CCC(O)=O)C(O)=O)=O)CCC(O)=O)=O)C(N[C@H](C(NC1=CC=C(C(O)C(NCCCCCN2C(C=CC2=O)=O)=O)C=C1)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C40H57N9O15/c1-22(2)33(48-35(58)25(12-16-31(53)54)44-21-28(50)46-27(39(62)63)13-17-32(55)56)37(60)47-26(7-6-19-43-40(41)64)36(59)45-24-10-8-23(9-11-24)34(57)38(61)42-18-4-3-5-20-49-29(51)14-15-30(49)52/h8-11,14-15,22,25-27,33-34,44,57H,3-7,12-13,16-21H2,1-2H3,(H,42,61)(H,45,59)(H,46,50)(H,47,60)(H,48,58)(H,53,54)(H,55,56)(H,62,63)(H3,41,43,64)/t25-,26-,27-,33-,34?/m0/s1
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| InChIKey |
CKXKMESVQUYELL-RWHWTACTSA-N
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| Pharmaceutical Properties |
Molecule Weight
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903.944
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Polar area
|
382.16
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Complexity
|
1788.088256
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xlogp Value
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-1.7987
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Heavy Count
|
64
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Rot Bonds
|
30
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Hbond acc
|
13
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker