Linker Information
General Information of This Linker
| Linker ID |
LIN0CGPWF
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|---|---|---|---|---|---|---|
| Linker Name |
TW202506738A-C-172-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C55H84N8O19
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOCC(NCCCC[C@H](NC(CCC(N(CCN(C1=O)C(C=C1)=O)CCN2C(C=CC2=O)=O)=O)=O)C(NCCCC(N[C@H](C(NC(C=C3)=CC=C3C)=O)C)=O)=O)=O
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| InChI |
InChI=1S/C55H84N8O19/c1-42-9-11-44(12-10-42)59-54(72)43(2)58-46(64)8-6-20-57-55(73)45(60-47(65)13-14-49(67)61(21-23-62-50(68)15-16-51(62)69)22-24-63-52(70)17-18-53(63)71)7-4-5-19-56-48(66)41-82-40-39-81-38-37-80-36-35-79-34-33-78-32-31-77-30-29-76-28-27-75-26-25-74-3/h9-12,15-18,43,45H,4-8,13-14,19-41H2,1-3H3,(H,56,66)(H,57,73)(H,58,64)(H,59,72)(H,60,65)/t43-,45-/m0/s1
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| InChIKey |
KZWNSVCWCODPOW-QCDYIZFSSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1161.314
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Polar area
|
323.64
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Complexity
|
2018.288351
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xlogp Value
|
-0.65608
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Heavy Count
|
82
|
Rot Bonds
|
49
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Hbond acc
|
19
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker