Linker Information
General Information of This Linker
| Linker ID |
LIN0CDXHW
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| Linker Name |
CN116916962A-C-41-linker
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C21H26N4O6
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| Isosmiles |
C[C@H](NC([C@@H](NC(CN1C(C=CC1=O)=O)=O)C(C)C)=O)C(NC2=CC=C(CO)C=C2)=O
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| InChI |
InChI=1S/C21H26N4O6/c1-12(2)19(24-16(27)10-25-17(28)8-9-18(25)29)21(31)22-13(3)20(30)23-15-6-4-14(11-26)5-7-15/h4-9,12-13,19,26H,10-11H2,1-3H3,(H,22,31)(H,23,30)(H,24,27)/t13-,19-/m0/s1
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| InChIKey |
KAOLHOUBBLHAKZ-DJJJIMSYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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430.461
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Polar area
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144.91
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Complexity
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837.8043156
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xlogp Value
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-0.3121
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Heavy Count
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31
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Rot Bonds
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9
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Hbond acc
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6
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN116916962A-ADC-B16 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
2.46 nM
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High hCCR2 expression (hCCR2+++) | ||
| Method Description |
THP 1, 15,000cells/254uL per welld were plated at set in 384 well flat plate, in the appropriate growth media. The cell plates were dosed with 5uL of the hCCR2 targeting-ADC samples and then incubated at 37°C for 20 hours. At the end of the incubation 10uL/well of the QUANTJ-LucTM (InvivoGenftrep-qlc1) were added and luminescence was measured immediately using the LeadSeeker.
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP1 cells | CVCL_0006 | ||