Linker Information
General Information of This Linker
| Linker ID |
LIN0CDMIU
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| Linker Name |
TW202506738A-C-133-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C48H60N10O12
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| Isosmiles |
C[C@H](NC(CCCNC([C@@H](NC(CCCN1C(C=CC1=O)=O)=O)[C@H](NC(CCCN2C(C=CC2=O)=O)=O)C(NCCCC(N[C@H](C(NC(C=C3)=CC=C3C)=O)C)=O)=O)=O)=O)C(NC(C=C4)=CC=C4C)=O
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| InChI |
InChI=1S/C48H60N10O12/c1-29-13-17-33(18-14-29)53-45(67)31(3)51-35(59)9-5-25-49-47(69)43(55-37(61)11-7-27-57-39(63)21-22-40(57)64)44(56-38(62)12-8-28-58-41(65)23-24-42(58)66)48(70)50-26-6-10-36(60)52-32(4)46(68)54-34-19-15-30(2)16-20-34/h13-24,31-32,43-44H,5-12,25-28H2,1-4H3,(H,49,69)(H,50,70)(H,51,59)(H,52,60)(H,53,67)(H,54,68)(H,55,61)(H,56,62)/t31-,32-,43-,44-/m0/s1
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| InChIKey |
IWKRACRJWOUORO-XAGGQHATSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
969.066
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Polar area
|
307.56
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Complexity
|
2082.239156
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xlogp Value
|
0.06284
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Heavy Count
|
70
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Rot Bonds
|
27
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Hbond acc
|
12
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker