Linker Information
General Information of This Linker
| Linker ID |
LIN0CDETL
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| Linker Name |
CN110997010A ADC-32 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C68H97N11O18S2
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| Isosmiles |
CC([C@H](N(C)C(CCCCCN1C(CC(SCC(NC(C(NC(CCCCCN2C(CCC2=O)=O)=O)CSC(CC3=O)C(N3CCCCCC(N(C)[C@H](C(N[C@@H](C)C(NC4=CC=C(CO)C=C4)=O)=O)C(C)C)=O)=O)=O)C(O)=O)C1=O)=O)=O)C(N[C@@H](C)C(NC5=CC=C(CO)C=C5)=O)=O)C
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| InChI |
InChI=1S/C68H97N11O18S2/c1-40(2)59(64(92)69-42(5)61(89)71-46-25-21-44(36-80)22-26-46)75(7)53(83)19-13-10-16-32-78-57(87)34-50(66(78)94)98-38-48(73-52(82)18-12-9-15-31-77-55(85)29-30-56(77)86)63(91)74-49(68(96)97)39-99-51-35-58(88)79(67(51)95)33-17-11-14-20-54(84)76(8)60(41(3)4)65(93)70-43(6)62(90)72-47-27-23-45(37-81)24-28-47/h21-28,40-43,48-51,59-60,80-81H,9-20,29-39H2,1-8H3,(H,69,92)(H,70,93)(H,71,89)(H,72,90)(H,73,82)(H,74,91)(H,96,97)/t42-,43-,48?,49?,50?,51?,59-,60-/m0/s1
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| InChIKey |
BKSTXOQADWTASL-IKKUZQNKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1420.717
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Polar area
|
405.12
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Complexity
|
3084.088039
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xlogp Value
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2.8296
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Heavy Count
|
99
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Rot Bonds
|
42
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Hbond acc
|
19
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker