Linker Information
General Information of This Linker
| Linker ID |
LIN0CBCMS
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|---|---|---|---|---|---|---|
| Linker Name |
WO2024105205A1-14m-170-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C18H24N4O9
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| Isosmiles |
NC(C[C@H](NC([C@H](CC(O)=O)NC(CCCCCN1C(C=CC1=O)=O)=O)=O)C(O)=O)=O
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| InChI |
InChI=1S/C18H24N4O9/c19-12(23)8-11(18(30)31)21-17(29)10(9-16(27)28)20-13(24)4-2-1-3-7-22-14(25)5-6-15(22)26/h5-6,10-11H,1-4,7-9H2,(H2,19,23)(H,20,24)(H,21,29)(H,27,28)(H,30,31)/t10-,11-/m0/s1
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| InChIKey |
ZAPORNFYMJYSPT-QWRGUYRKSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
440.409
|
Polar area
|
213.27
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Complexity
|
732.9078157
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xlogp Value
|
-2.1239
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Heavy Count
|
31
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Rot Bonds
|
14
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Hbond acc
|
7
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker