Linker Information
General Information of This Linker
| Linker ID |
LIN0BYJTM
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
NH2-PEG4-EvcPAB
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C35H57N7O14
|
|||||
| Isosmiles |
CC([C@H](NC([C@@H](NC(CCOCCOCCOCCOCCN)=O)CCC(O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)COC(O)=O)=O)=O)C
|
|||||
| InChI |
InChI=1S/C35H57N7O14/c1-23(2)30(33(48)41-26(4-3-13-38-34(37)49)31(46)39-25-7-5-24(6-8-25)22-56-35(50)51)42-32(47)27(9-10-29(44)45)40-28(43)11-14-52-16-18-54-20-21-55-19-17-53-15-12-36/h5-8,23,26-27,30H,3-4,9-22,36H2,1-2H3,(H,39,46)(H,40,43)(H,41,48)(H,42,47)(H,44,45)(H,50,51)(H3,37,38,49)/t26-,27-,30-/m0/s1
|
|||||
| InChIKey |
HRKDQIYMBJATCB-VWYPKUQYSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
799.876
|
Polar area
|
318.29
|
||
|
Complexity
|
1293.748166
|
xlogp Value
|
-0.3414
|
|||
|
Heavy Count
|
56
|
Rot Bonds
|
31
|
|||
|
Hbond acc
|
13
|
Hbond Donor
|
9
|
|||
Each Antibody-drug Conjugate Related to This Linker