Linker Information
General Information of This Linker
| Linker ID |
LIN0BWREZ
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| Linker Name |
Aminobenzazepine-linker Formula II-16
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C14H16F4N2O4
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| Isosmiles |
FC1=C(OC(CCOCCC(NCCN)=O)=O)C(F)=C(F)C=C1F
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| InChI |
InChI=1S/C14H16F4N2O4/c15-8-7-9(16)13(18)14(12(8)17)24-11(22)2-6-23-5-1-10(21)20-4-3-19/h7H,1-6,19H2,(H,20,21)
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| InChIKey |
UAMJHXBSRQYLEV-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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352.284
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Polar area
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90.65
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Complexity
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533.6413094
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xlogp Value
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1.0201
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Heavy Count
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24
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Rot Bonds
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9
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Hbond acc
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5
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Hbond Donor
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2
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-10 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||