Linker Information
General Information of This Linker
| Linker ID |
LIN0BTSZC
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| Linker Name |
COT-GGG-E linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C21H31N5O8
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| Isosmiles |
O=C(NCC(NCC(NCC(N[C@@H](CCC(O)=O)C(N)=O)=O)=O)=O)COC1CCCCCC#C1
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| InChI |
InChI=1S/C21H31N5O8/c22-21(33)15(8-9-20(31)32)26-18(29)12-24-16(27)10-23-17(28)11-25-19(30)13-34-14-6-4-2-1-3-5-7-14/h14-15H,1-4,6,8-13H2,(H2,22,33)(H,23,28)(H,24,27)(H,25,30)(H,26,29)(H,31,32)/t14?,15-/m0/s1
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| InChIKey |
DBUXSJBAIWTDES-LOACHALJSA-N
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| Pharmaceutical Properties |
Molecule Weight
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481.506
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Polar area
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206.02
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Complexity
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774.591289
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xlogp Value
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-2.4774
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Heavy Count
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34
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Rot Bonds
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14
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Hbond acc
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7
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A- LP21-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.023 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 42% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||