Linker Information
General Information of This Linker
| Linker ID |
LIN0BQSTH
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
WO2024140449A1+ADC17+Linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C22H38BrN7O10
|
|||||
| Isosmiles |
C[C@@H](NC(C(NC(CNC(CCOCCOCCNC(CBr)=O)=O)=O)C(C)C)=O)C(NCC(NNC(O)=O)=O)=O
|
|||||
| InChI |
InChI=1S/C22H38BrN7O10/c1-13(2)19(21(36)27-14(3)20(35)26-12-18(34)29-30-22(37)38)28-17(33)11-25-15(31)4-6-39-8-9-40-7-5-24-16(32)10-23/h13-14,19,30H,4-12H2,1-3H3,(H,24,32)(H,25,31)(H,26,35)(H,27,36)(H,28,33)(H,29,34)(H,37,38)/t14-,19?/m1/s1
|
|||||
| InChIKey |
MIRHBHSJLAFJOS-MJTSIZKDSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
640.489
|
Polar area
|
242.39
|
||
|
Complexity
|
812.976375
|
xlogp Value
|
-2.9025
|
|||
|
Heavy Count
|
40
|
Rot Bonds
|
19
|
|||
|
Hbond acc
|
9
|
Hbond Donor
|
8
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024140449A1 ADC18 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 5 nM | |||
| Method Description |
A Cell line test onNCI-H1975
|
||||
| In Vitro Model | Lung adenocarcinoma | NCI-H1975 cells | CVCL_1511 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 5 nM | |||
| Method Description |
A Cell line test on OE-33
|
||||
| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||